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Research Journal of Pharmacognosy and Phytochemistry
Year : 2010, Volume : 2, Issue : 2
First page : ( 136) Last page : ( 139)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.

Hepatoprotective Activity of Oxalis corniculata Leaves against Carbon Tetrachloride Induced Hepatotoxicity in Female Albino Wistar Rats

Jadhav Anil G1,*, Patil Mrutyunjay B1, Narkhede Sachin B2, Sagar G Vidya3

1KLES College of Pharmacy, Belgaum, Karnataka, India

2Smt.BNB Swaminarayan Pharmacy College, Salvav (Vapi)

3Dean, Veerayatan institute of pharmacy, kutch-370 460, gujarat

*Corresponding Author: Anil G Jadhav, KLES College of Pharmacy, Belgaum, Karnataka, India. Email: jadhavanil_29@rediffmail.com Ph. No. 09909220894.

Online published on 21 March, 2013.

Abstract

In recent times lot of interest has been generated to find out a natural remedy for hepatic disorders caused by toxins like alcohol and hepatitis virus. The present study is designed and investigate the hepatoprotective activity of Oxalis corniculata leaves against carbon tetrachloride (CCl4) induced hepatotoxicity in female Albino Wistar rats. Forty two Albino Wistar female rats were divided in to seven equal groups each containing six animals. Four groups received the extracts of Oxalis corniculata leaves and intraperitoneal (i.p.) CCl4 (2 ml/kg) with administration of extracts. One group was control, one treated with CCl4 and one with normal saline. The hepatotoxicity was assessing by plasma concentration of serum bilirubin and enzymes activities. The aqueous extract (500mg/kg b.w) of Oxalis corniculata significantly reduced carbon tetrachloride induce damages in the liver which is measured by SGOT, SGPT, SALP and serum bilirubin levels in blood. The attempt has been made to extract the active constituent and identified by phytochemical investigation and hepatoprotective activity of leaves of Oxalis corniculata.

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Keywords

Oxalis corniculata, carbon tetrachloride, hepatoprotective.

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