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Research Journal of Pharmacognosy and Phytochemistry
Year : 2020, Volume : 12, Issue : 3
First page : ( 145) Last page : ( 148)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2020.00024.2

Formulation and evaluation of polyherbal aqueous gel from Psidium guajava, Piper betel and Glycerrhiza glabra extract for mouth ulcer treatment

Jain Nem Kumar1,*, Roy Rituparna1, Pathan Hero Khan1, Sharma Aditi1, Ghosh Shakhi1, Kumar Santosh2

1School of Pharmacy, ITM University, Gwalior, Madhya Pradesh, India

2Department of Life Sciences, ITM University, Gwalior, Madhya Pradesh, India

*Corresponding Author E-mail: nemkumar89@gmail.com

Online published on 16 September, 2020.


Mouth ulcers often cause pain and irritation of the sores by salty, spicy and sour food items and may cause discomfort while healing occurs due to the use of chemical formulations. This project focuses on the preparation of a herbal mouth ulcer healing gel because of better cultural acceptability, better compatibility with human body and lesser side effects. The gel was prepared by using alcoholic extract of Psidium guajava, and betel leaves and aqueous extract of liquorice. Developed formulations were transparent, homogeneous and pH ranges from 6.8–7. Formulation showed acceptable rheological behaviour with applicable Spreadability and Extrudability properties. Anti-fungal studies of formulations showed excellent efficacy against Aspargilious aureus, Candida albicans. Therefore, developed formulations have potential to treat mouth ulcers. However, further clinical studies are required to establish clinical efficacy of prepared herbal gels.



Guava leaves, Betel leaves, Liquorice root, Mouth ulcers, Polyherbal, Gel.


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