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Research Journal of Pharmacognosy and Phytochemistry
Year : 2019, Volume : 11, Issue : 3
First page : ( 145) Last page : ( 149)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2019.00024.4

Advances in Zika Virus Host-Cell Interaction: Current Knowledge and Future Perspectives

Priya Asawa, Naincy Varshney, Siddhsssarth Gupta, Vivek Pandey, Manali Singh*

Department of Biotechnology, Invertis University, Bareilly

*Corresponding Author E-mail: manalisingh15@gmail.com

Online published on 31 December, 2019.

Abstract

Emerging mosquito-transmitted RNA viruses, such as ZIKA virus (ZIKV) and Chikungunya represent human pathogens of an immense global health problem. ZIKV has emerged explosively since 2007 to cause a series of epidemics in the South Pacific and most recently in the Americans. Although typical ZIKV infection are asymptomatic, ZIKV infection during pregnancy is increasingly associated with microcephaly and other foetal developmental abnormalities. In the last few years, genomic and molecular investigation have established a remarkable progress on the pathogenic mechanism of ZIKV infection using invitro and invivo models. Here, we highlight recent advances in ZIKV-host cell interaction studies, including cellular targets of ZIKV, ZIKV-mediated cell death mechanisms, host cell restriction factors that limit ZIKV replication and immune evasion mechanisms utilized by ZIKV. By understanding the mechanism and machinary of ZIKV-host interaction at the cellular level will contribute crucial insights for the development of therapeutics and vaccines.

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Keywords

ZIKA virus, cell death, cellular targets, innate immune evasion.

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