Anti-inflammatory activity of Prinsepia utilis flower extract in Wistar rats Thakur Vinay1,*, Guleria Rajender2, Singh Ranjit3 1Pacific University, Pacific Hills, Pratapnagar, Debari, Udaipur, Rajasthan, India 2Govt. College of Pharmacy, Rohru Distt. Shimla, Himachal Pradesh 3Adrash Vijendra Institute of Pharmaceutical Sciences, Shobit Univesity, Gangoh, Saharanpur, Uttar Pradesh, India *Corresponding Author E-mail: rxvinay@yahoo.com
Online published on 27 December, 2018. Abstract Objective Evaluation of antiinflammatory activity of methanolic flower extracts of Prinsepis utlis in wistar rats. Background: Prinsepis utilis belanging to family Rosaceae is commonly known as “Himalayan cherry” and widely distributed throughout the mid Himalayan range. The different parts of plant find folklore use for variety of conditions and ailments. The seeds have rubefacient property and used in rheumatism and pain. Roots have wound healing and antidote properties, leaves and fruits are used in tonsillitis, stone pain and allergic conditions. Method The extract was prepared by continuous hot soxhlet extraction with pet ether, chloroform and methanol in increasing order of polarity. Wistar rats of either sex were used for the Carrageenan induced rat pedal enema. Rats were divided into four groups (control 0.9%NaCl 5ml/kg body wt, indomethacin 10mg/kg body wt, extract 100 and 200mg/kg body wt) each having six rats. Results: The methanolic extracts of P. utilis exhibited significant anti-inflammatory activity at both doses of 100mg/kg body weight and 200mg/kg body weight. Extract 100mg/kg body weight produced 64.38% inhibition and 200mg/kg body weight exhibited 65.75% inhibition of paw edema at the end of three hours as compared to control. The inhibition of inflammation for both doses was comparable to indomethacin 69.86% (inhibitor of cyclooxygenase). Conclusion on the basis of above findings, it may be concluded that P. utilis has anti-inflammatory properties which block the release of inflammatory mediators. The results justify the folklore uses of plant. Top Keywords Prinsepia utilis, inflammation, edema, cyclooxygenase inhibitor. Top |