Evaluation of Anti-Hyperlipidemic and Anti Oxidant Activity of Ethanolic Extract of Delonix Elata on High fat diet Induced Rats
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The present study was designed to investigate the anti hyperlipidemic activity of aerial part of ethanolic extract Delonix elata (EEDE) in high fat diet induced hyperlipidemic rats.
In the present study, chronic administration of High fat diet (HFD) in rats produced significant increase in the body weight, total cholesterol (TC), high density lipoprotein (HDL), very low density lipoproteins (VLDL), low density lipoproteins (LDL), triglycerides (TG) and blood glucose levels. EEDE was administered at a dose of 250 and 500 mg/kg, (p.o) to high fat induced Hyperlipidemic rats. Atorvastatin (10 mg/kg) is used as reference standard.
EEDE shows a significant decrease (p<0.01) in the levels of serum cholesterol, triglycerides, LDL, VLDL and significant increase (p<0.01) in the level of serum HDL. The extract also showed a significant antioxidant activity. The levels of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase was increased significantly indicating the extract is having potent antioxidant activity. Histopathological studies were also observed.
From the above results it can be concluded that the antihyperlipidemic and antioxidant activity of ethanolic leaf extract of Delonix elata may be due to the presence of Flavonoids and Saponins
Delonix elata, High fat diet, Antioxidant, LDL, Hyperlipidemia.