(34.231.247.88)
Users online: 2564    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacognosy and Phytochemistry
Year : 2018, Volume : 10, Issue : 3
First page : ( 241) Last page : ( 245)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2018.00039.0

Evaluation of Anti-Hyperlipidemic and Anti Oxidant Activity of Ethanolic Extract of Delonix Elata on High fat diet Induced Rats

Babu S. Ravindra, Goud K. Priyanka*

Department of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad

*Corresponding Author E-mail: ravicology@gmail.com

Online published on 24 October, 2018.

Abstract

Objective

The present study was designed to investigate the anti hyperlipidemic activity of aerial part of ethanolic extract Delonix elata (EEDE) in high fat diet induced hyperlipidemic rats.

Methods

In the present study, chronic administration of High fat diet (HFD) in rats produced significant increase in the body weight, total cholesterol (TC), high density lipoprotein (HDL), very low density lipoproteins (VLDL), low density lipoproteins (LDL), triglycerides (TG) and blood glucose levels. EEDE was administered at a dose of 250 and 500 mg/kg, (p.o) to high fat induced Hyperlipidemic rats. Atorvastatin (10 mg/kg) is used as reference standard.

Results

EEDE shows a significant decrease (p<0.01) in the levels of serum cholesterol, triglycerides, LDL, VLDL and significant increase (p<0.01) in the level of serum HDL. The extract also showed a significant antioxidant activity. The levels of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase was increased significantly indicating the extract is having potent antioxidant activity. Histopathological studies were also observed.

Conclusion

From the above results it can be concluded that the antihyperlipidemic and antioxidant activity of ethanolic leaf extract of Delonix elata may be due to the presence of Flavonoids and Saponins

Top

Keywords

Delonix elata, High fat diet, Antioxidant, LDL, Hyperlipidemia.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
553,953,746 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.