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Research Journal of Pharmacognosy and Phytochemistry
Year : 2018, Volume : 10, Issue : 3
First page : ( 216) Last page : ( 220)
Print ISSN : 0975-2331. Online ISSN : 0975-4385.
Article DOI : 10.5958/0975-4385.2018.00035.3

Phytochemistry and Pharmacology of the Echinops integrifolius

Karimov U. T.1,2, Qing Zhao Hai2, Aisa H.A.2

1Institute of the Chemistry of Plant Substances AS RUz, Tashkent, 100170, Uzbekistan

2Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China

*Corresponding Author E-mail: ulugbek_chem@rambler.ru

Online published on 24 October, 2018.


For the first time investigated the sum of alkaloids of plant Echinops integrifolius, which totaled 0.186% of the dry weight of the plant. By column chromatography was isolated and identified eight substances: three triterpenoids, umbelliferone, isoprenoid γ-lactone-4, 8, 12, 16-tetrametilheptadekan-4-olide, dibuthyl phthalate. There have been studies of antidiabetic properties of isolated compounds, and obtained extracts. It was investigated the antidiabetic, and antimicrobial activity, influence of umbelliferone on tyrosinase activity and melanin in the cells of the model B16 (OD475).



Ethanol, extract, lupeol, lupeol acetate, umbelliferone, antidiabetic activity, tyrosinase, melanine.


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