Aphrodisiac studies of Pavetta crassicaulis Bremek. leaf, flower extract and it pure compounds using Wistar albino rats
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Pavetta crassicaulis Bremek.(F: Rubiaceae), an important ethno-medicinal shrub/small tree, belonging to the family Rubiaceae, grows up to 4 meter tall the plant is endemic to India. We aimed to assess the effects of Pavetta crassicaulis Bremek. leaf and flower extract and its isolated constituent 2-Tert-Butyl-4,6-Bis(3,5-DiTert-Butyl-4-Hydroxybenzyl)Phenol and 4H-Pyran-4-one,2,3-dihydro-3,5-dihydroxy-6-methyl-on Aphrodisiac activity. The aphrodisiac activity of Pavetta crassicaulis Bremek. leaf, flower extract and it pure compound were studied on male wistar albino rats at various dosages. The parameters observed during the study were mount frequency, mount latency, intromission frequency, intromission latency, ano-genital sniffing and genital grooming. The results revealed that, the crude extracts showed dose dependent activity in all the concentration in that, ethanolic flower extract showed excellent activity compared to ethanolic leaf extract and pure compound. The results gives the positive effect of Pavetta crassicaulis Bremek flower and leaf in the treatment of sexual disorders by the tribes of Odisha, India but the major compounds present in 2-Tert-Butyl-4,6-Bis(3,5-Di-TertButyl-4-Hydroxybenzyl)Phenol and 4H-Pyran-4-one,2,3-dihydro-3,5-dihydroxy-6-methyl-were not responsible for the aphrodisiac activity may be the minor compounds even though in least concentration may influence the sexual activity in tested animals.
Pavetta crassicaulis Bremek, 2-Tert-Butyl-4, 6-Bis(3, 5-Di-Tert-Butyl-4Hydroxybenzyl)Phenol, 4H-Pyran-4-one, 2, 3-dihydro-3, 5-dihydroxy-6-methyl-, Aphrodisiac activity.