Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System Shah Rutuja R., Shah Rutuja S., Vakhariya Rohan R.* Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India *Corresponding Author E-mail: rohanwakhariya@gmail.com
Online published on 24 May, 2018. Abstract Present research work was aimed to formulate and evaluate the gastro-retentive floating microballoons of glimepiride using hydrophilic polymers hydroxypropyl methylcellulose and Eudragit RS100 by emulsion solvent evaporation technique. The developed gastro retentive floating drug delivery system was evaluated for various parameters like micromeritic properties, buoyancy, in-vitro drug release, etc. It was observed that the drug delivery systems of glimepiride has shown excellent physicochemical properties, stability and controlled drug release pattern, by improving the bioavailability of the drug and also by managing the complicacy of the diabetes in a better manner. Top Keywords Floating microspheres, Glimepiride, in-vitro drug release, solubility. Top |