Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 4
First page : ( 173) Last page : ( 179)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00028.3

Formulation and Evaluation of Ondansetron Floating Tablet

Patle Lokesh*

Assistant Professor, Department of Pharmaceutics, Sardar Patel College of Technology (B. Pharmacy), Balaghat, M.P.

*Corresponding Author E-mail: lokesh.patle10@gmail.com

Online published on 24 May, 2018.

Abstract

Some drugs are absorbed in a particular portion of the GIT only or are absorbed to a different extent in various segments of the GIT. Such drugs are said to have an absorption window, which identifies the drug's primary region of absorption in the GIT. Gastroretentive tablets of Ondansetron hcl were successfully prepared by effervescent technique using different gel forming polymers-HPMC (K15M, K4M, 15cps, 3cps), and carbopol 934. Formulation was optimized on basis of floating time and invitro release. The prepared gastroretentive test formulation was found to exhibit satisfactory physico-chemical characteristics at the end of 30 days, during the stability studies. The optimized formulation was found to be stable at 40°C/75% RH.

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Keywords

Absorption window, effervescent technique, HPMC, carbopol 934, floating time, stability studies.

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