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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2017, Volume : 9, Issue : 4
First page : ( 147) Last page : ( 157)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2017.00024.6

Formulation Techniques for Designing of Osmotic Controlled Drug Delivery Systems: A Review

Sahoo Chinmaya Keshari1,*, Rao Surepalli Rammohan2, Sudhakar Muvvala3, Ramana D. Venkata4, Panda Kanhu Charan5

1Ph. D Scholar, Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana-500007

2Professor of Chemical Engineering, Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia

3Professor and Principal, Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affiliated to Osmania University), Maisammaguda, Secunderabad, Telangana-500014

4Professor and Principal, Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana-508252

5Associate Professor, Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana

*Corresponding Author E-mail: sahoo.chinmaya83@gmail.com

Online published on 24 May, 2018.


Osmotic drug delivery system (ODDS) provides the drug dose and dosing interval in optimized manner to maintain drug concentration within therapeutic window thus ensuring efficacy and minimizing toxic effects. The objective of ODDS is to release pharmacologically active ingredients in a predetermined, predictable and reproducible manner to systemic circulation. ODDS delivers a drug to large extent is independent of the physiological factors of the gastrointestinal tract, pH. Hence it can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system controls the drug release by controlling various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane. The design of osmotic system is achieved by optimizing formulation and processing factors to deliver drugs in preprogrammed rate and controlled manner. In present study is an update on osmosis, different types of osmotic systems, components of ODDS, key parameter sand some patents.



Osmotic drug delivery system, osmosis, osmotic pressure.


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