Determination of Effect of pH, Temperature and RPM on dissolution of Telmisartan by Two Factorial Design Nafees Sheema S*, Basha Sayad K, Thirumalesh S.B. Department of Pharmaceutics, JNTUA-Oil Technological Research Institute, Ananthapuram, A.P., India *Corresponding Author E-mail: sheemanafees5@gmail.com
Online published on 2 February, 2017. Abstract The main intend of present study was to determine how the dissolution parameters such as rpm, temperature and pH affects drug release for the marketed Telmisartan IR tablets. They were quantitatively and statistically studied by applying two factorial design. The dissolution parameters like temperature of the medium, pH of the medium and rpm were taken from low level to high levels and factorial design was applied at-1, +1 levels. The experiment was performed and drug release was estimated. Factorial design proved, the drug release up to 90% within 30 min. Finally, change in pH was found to be having more prominent effect on drug release than temperature and rpm. Top Keywords Dissolution, Temperature, RPM, pH, Factorial Design. Top |