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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 4
First page : ( 256) Last page : ( 260)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00036.1

Formulation and Evaluation of Atorvastatin Calcium Floating Tablets by using Xanthum Gum as a Release Modifying Agent

Mogal Nitin1, Kulkarni Snehal1, Deshpande Swapnil2,*, Vishwe Pradnya2

1JSPM'S Jayawantrao Sawant College of Pharmacy and Research, Pune

2SCSSS's Sitabai Thite College of Pharmacy, Shirur, Pune-412 210

*Address for correspondence: Swapnil Deshpande, SCSSS's Sitabai Thite College of Pharmacy, Shirur, Pune-412 210, E-mail: swapnil.std@gmail.com

Online published on 8 December, 2015.

Abstract

Gastroretentive floating controlled drug delivery system containing Atorvastatin calcium was prepared in the form of tablets and evaluating the various processing parameters including the buoyancy studies and in vitro drug release studies in 0.1 N HCl (PH 1.2). Nine formulations containing varying proportions of polymers HPMC K4M, Xanthum gum and fixed amount of Sodium bicarbonate and Citric acid are gas (CO2) forming agents (Sodium bicarbonate are alkalizing agents, Citric acid are Buffering agents), Magnesium stearate Lactose were used as lubricant and diluent respectively. The tablets were prepared by direct compression Method, and the prepared tablets remained buoyant for more than 12 hrs in the release medium. The proportions of the polymers showed significant difference in the release of the drug. Xanthum gum is used as a release modifying agents because it swell and form a gel in acidic medium and which is more stable in acidic medium.

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Keywords

Floating tablets, Buoyancy, Controlled release, Atorvastatin calcium, Xanthum gum.

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