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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2015, Volume : 7, Issue : 2
First page : ( 134) Last page : ( 142)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2015.00020.8

Formulation and Evaluation of Controlled Release Matrix Tablets of Sotalol

Kathija Mufeeda1,*,**,  Ravikumar1, Nureesha Ayshath1, Narayanaswamy V.B2

1Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore-575028, Karnataka, India

2Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore-575028, Karnataka, India

*Corresponding Author E-mail: mailmufeeda@gmail.com

**Address for correspondence: Mufeeda Kathija, Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore-575028, Karnataka, India

Online published on 25 June, 2015.

Abstract

The present study aimed at Formulation Development and Evaluation of controlled release tablets for the programmed release of sotalol hydrochloride for the treatment of Arrhythmia. The matrix tablets of sotalol hydrochloride were prepared using wet granulation. Physical characterization of tablet and powder blends used to form the matrix tablet was under taken using a range of experimental techniques. Instacoat EN II was used as enteric coat polymer for coating the matrix tablet. Dissolution studies of sotalol hydrochloride controlled release tablets in media with different dissolution media 0.1 N HCl, pH (7.4) as per US Pharmacopeia. The study showed that, drug release in 2hr was highly affected by the coating level. The dissolution data revealed that the % of coating, ratio of polymers and concentration of Compritol 888 ATO are very important to achieve a optimum formulation. Dissolution shows that the drug release from F12 is very similar to Marketed brand (Sotalar). Stability study of the optimized formulation indicates no significant difference in release profile after a period of one month.

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Keywords

Sotalol hydrochloride, Arrhythmia, Controlled release tablets, Compritol 888 ATO, Sotalar, Instacoat EN II.

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