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Year : 2020, Volume : 12, Issue : 4
First page : ( 261) Last page : ( 266)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00043.9

Nanosponge a novel drug delivery system

Balwe Manish Bandu*

Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206.

*Corresponding Author E-mail: balwemanish@gmail.com

Online published on 10 February, 2021.


Nanosponge is a targeted drug delivery system in that active pharmaceutical agent is respectively targeted to its site of action and not to the non-targeted organs, tissues or cells. Nanosponges modern effective drug carriers which decrease the problems of toxicity and increase bioavailability of both hydrophilic and hydrophobic drugs. Nanosponge is a modern drug delivery system, is one of the most promising approaches in the life science. Nanosponges are tiny mesh like structure, a three dimensional network and nanometric cavity. Nanosponges are highly porous in nature and they have ability to entrap active molecules. Cyclodextrins and other appropriate crosslinking agents in a specified ratio use for prepration of nanosponge. Nanosponges fast absorb in the body until they reach the specific target site, stick on the surface and release the drug in control manner. Nanosponge have a high drug loading capacity as compare to other nanocavity. Hence they have high stability, solubility and delayed release of actives. Specially nanosponge is use for a loading of low water soluble drug and targeting to its specific site, it's a advantage of nanosponge. Nanosponge can deliver the drugs in different routes like oral, topical, parentral etc. and act as vehical t in the delivery of enzymes, proteins, vaccines and antibodies. Thise review explain the characteristic features (advantage and disadvantage), preparation methods, factors, characterization, and applications of nanosponges in the field of drug delivery.



Nanosponges, Cyclodextrins, Cross-linking agents, Controlled release.


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