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RESEARCH JOURNAL OF PHARMACEUTICAL DOSAGE FORMS AND TECHNOLOGY
Year : 2020, Volume : 12, Issue : 4
First page : ( 258) Last page : ( 260)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00042.7

Toxicological evaluation of Psidium guajava leaf extracts using brine shrimp (Artemia salina L.) model

Yadav Akshay R.*, Mohite Shrinivas K.

Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India - 415404.

*Corresponding Author E-mail: akshayyadav24197@gmail.com

Online published on 10 February, 2021.

Abstract

The search for new plant-derived drugs has gained renewed interest among researchers worldwide in the hunt for new drugs that have the potential to combat the threat of drug-resistant pathogenic microorganisms, antitumor and anticancer agents. Plants can be useful in either their crude or advanced forms, offering their pure state a source of drugs. Brine Shrimp Lethality Assay is the most convenient system to monitor the biological activity of different species of plants. This approach is very useful for the toxicity evaluation of plant extracts in advance. This assay has many advantages: rapidity, simplicity and low requirements. However, several requirements need to be fulfilled, especially with standardized experimental conditions (temperature, medium pH, salinity, aeration, and light). Psidiumguajava leaves have long been in use in the Indian Local Medicine System for their antioxidant and anti-inflammatory properties. The toxicity of Psidiumguajava leaf extracts using this assay was determined within a concentration range of 1mg/ml, 100^g/ml, 10^g/ml and 1^g/ml of the herbal extract being tested. After 24 hours of exposure to the studied sample, most toxicity studies using the Brine Shrimp Lethality Assay assess toxicity. The Brine Shrimp Lethality Assay is an excellent predictive tool for the toxic potential of plant extracts in humans.

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Keywords

Brine shrimp lethality assay, Psidiumguajava, Toxicity testing, Artemiasalina.

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