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RESEARCH JOURNAL OF PHARMACEUTICAL DOSAGE FORMS AND TECHNOLOGY
Year : 2020, Volume : 12, Issue : 4
First page : ( 245) Last page : ( 248)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00040.3

Formulation and in-vitro evaluation of sustained release matrix tablets of valsartan using beta-cyclodextrin

Khan Hamid*

Sanskar City College of Pharmacy, Rajnandgaon, Chhattisgarh, India.

*Corresponding Author E-mail: khanhamid770@gmail.com

Online published on 10 February, 2021.

Abstract

In the presented work formulation and in-vitro evaluation was carried out for tablets containing Valsartan as Sustained Release using HPMC and Beta-Cyclodextrin polymers by wet granulation method. The tablets were subjected to in-vitro drug release study in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The drug released at various time intervals were determined by validated UPLC-PDA method. The prepared tablets showed better sustained release effect when compared with marketed tablets. The formulated tablets provided sustained release of Valsartan over a period of 24 h.

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Keywords

Valsartan, Beta-Cyclodextrin, HPMC, Hydrophilic polymer, Sustained release.

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