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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2020, Volume : 12, Issue : 2
First page : ( 105) Last page : ( 110)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00019.1

Improved Monocyte in the Transport of Drug into The Brain Pilot Plant Scale up for Tablet

Sharma Saloni*, Patil Amit B., Gowda DV

Department of Industrial Pharmacy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka – 560078, India

*Corresponding Author E-mail: salpalrockzz@gmail.com, amitbpatil@jssuni.edu.in, dvgowda@jssuni.edu.in

Online published on 10 August, 2020.

Abstract

The study is enlisted about the capability of the monocytes and its derivated macrophages (MDM) to travel through the CNS system for the drug disposition and to overcome all the barriers that come in between during the drug transportation into the brain to prevent and to reduce brain inflammation during monocyte transferring drug at the site of inflamed brain of the mouse. Preparation of mouse monocytes are also shown as cell carriers for drug disposition in case of mouse its in the bone marrow region. Different toxic effects, biological mechanisms and in vitro and in vivo were studied. To prevent the attack of these effects in the brain, different technologies were improved to administer monocyte-derived drug carriers. Administration of a formulation of the drug was introduced eg. Serotonin at the site of the affected region was examined for its healing effects in the mouse. Its body distribution, drug penetration, drug composition qualitative and quantitative analysis were studied. The mechanism of brain transport is also illustrated.

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Keywords

Monocyte, Transport of Drug, Brain.

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