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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2020, Volume : 12, Issue : 2
First page : ( 68) Last page : ( 72)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00012.9

Formulation and In Vitro Evaluation of Phenytoin Sodium Sustained Release Matrix tablet

Dr Reddy Y. Krishna*, Aravind A.

Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana

*Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 10 August, 2020.


In this study an attempt was made to formulate and evaluate sustained release matrix tablets of Phenytoin Sodium using Carbopol 934, Eudragit and HPMC K100 as the retardant polymer. Tablets were prepared by direct compressioin technique. Tablets were evaluated for parameters such as weight variation, hardness, friability and drug content. All the formulations showed compliance with pharmacopieal standards. In vitro release studies were performed using USP type II apparatus (paddle method) in 900 mL of 0.1N HCl at 50 rpm for 2 hours and remaining 10 hours 6.8 Phosphate Buffer. The release kinetics was analyzed using the zeroorder, first order, Higuchi, and Korsmeyer-Peppas equations to explore and explain the mechanism of drug release from the matrix tablets. In vitro release studies revealed that percent drug release increased with increase of polymer loading. Based on the dissolution data comparison with innovator brand F-6 formulation (Eudragit) was elected as the best formulation. The drug release profile of the best formulation was well controlled and uniform throughout the dissolution studies.



Phenytoin Sodium, Carbopol 934, Eudragit, HPMC K100 and Sustained release tablets.


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