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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2020, Volume : 12, Issue : 2
First page : ( 53) Last page : ( 57)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00009.9

Formulation and Evaluation of Extended Release Tablets of an Anti-Bacterial Drug Cephalexin

Dr Reddy Y. Krishna*, Lakhpathi

Department of Pharmaceutics, Nalanda College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana

*Corresponding Author E-mail: rajinisuralabs1@gmail.com

Online published on 10 August, 2020.

Abstract

The design of extended release tablet by using natural polymers are becoming very popular in formulating oral extended release tablet as they are biocompatible, biodegradable, non-toxic, cheap and easily available compared to synthetic polymers. The present investigation was planned to formulate and evaluate the Cephalexin extended release tablets with natural polymers like Xanthan gum, Karaya gum and Guar Gum. Drug-excipient compatibility study was conducted using FTIR spectroscopy. The procedure adopted to make the compacts was via direct compressions. The tablets were also evaluated for physicochemical characteristics and release kinetics and it was satisfactory. The developed drug delivery systems showed prolonged drug release rates over a period of 14 h. The release profile of the optimized formulation (C4) was described by the zero-order model.

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Keywords

Cephalexin, Xanthan gum, Karaya gum, Guar Gum, Extended release tablets and Direct compression method.

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