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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2020, Volume : 12, Issue : 1
First page : ( 13) Last page : ( 16)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2020.00003.8

Preparation and Evaluation of Fast Dissolving Oral Film of Losartan Potassium

Sadique Sara1,*, Ramya Sri S.2

1Department of Pharmaceutics, Global College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India

2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India

*Corresponding Author E-mail: ramyasuralabs2@gmail.com

Online published on 10 August, 2020.

Abstract

The fast dissolving oral film of losartan potassium were prepared using different polymers like PVP, HPMC and Pectin by solvent casting method. The fast dissolving oral film evaluated for folding endurance, swelling index, surface pH, in vitro disintegration time, drug content, drug polymer compatibility (IR Study), and in vitro drug release. The physical appearance and folding endurance properties were found to be good. The average folding endurance time within the range of 112 to 208. The drug content showed uniform mixing of drug in all prepared fast dissolving films. The in vitro drug release showed 78 to 96% drug release within 5 minutes. Drug release obeys the first order kinetics. Hence it can be inferred that the fast dissolving oral film of losartan potassium may produce the rapid action thereby improving bioavilability and enhance the absorption by avoiding the first pass effect.

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Keywords

Losartan Potassium, oral film.

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