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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2019, Volume : 11, Issue : 1
First page : ( 53) Last page : ( 63)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2019.00009.0

Formulation and Evaluation of Oral Disintegrating Tablets of Ondansetron Hydrochloride

Chanda Ranabir*, Padmalata H., Venkatesh, Banerjee Janmajoy

Gyana Jyothi College of Pharmacy, Uppal Bus Dept. Hyderabad, India

*Corresponding Author E-mail: ranabirchanda@gmail.com

Online published on 16 March, 2019.


In the present work, oral disintegrating tablets of Ondansetron Hydrochloride were developed with a view to enhance the patient compliance and provide quick onset of action. Since Ondansetron Hydrochloride is highly bitter drug, taste masking is done by using Polyethylene glycol-6000 as carrier to form solid dispersed granules and these granules are further coated with Hydroxy propyl methyl cellulose. The drug-solid dispersed coated granules showed no bitterness in the taste. Oral disintegrating tablets prepared by direct compression method using superdisintegrants like crospovidone, croscarmellose sodium, sodium starch glycolate, kyron T-314 and combination of crospovidone with croscarmellose sodium, crospovidone with sodium starch glycolate and crospovidone with kyron T-314 in different concentration and evaluated for the pre-compression parameters such as bulk density, compressibility, haunser ratio and angle of repose. The prepared batches of tablets were evaluated for hardness, weight variation, thickness, friability, drug content, disintegration time, wetting time, invitro dispersion time, and in vitro dissolution profile and found satisfactory. Among all, the formualation F14 containing CP 3% + CCS 1.5% (2: 1 ratio) was considered to be the best formulation, which releases up to 100.09% of the drug in 8 min and disintegration time is 10 sec.



Ondansetron Hydrochloride, Oro-dispersible tablets, Super disintegrants, Sodium starch glycolate, Croscarmellose sodium, Crospovidone, Kyron T-314.


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