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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 3
First page : ( 179) Last page : ( 187)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00028.9

Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablets for Oral Delivery of Stavudine

Sahoo Chinmaya Keshari1,*, Rao Surepalli Ram Mohan2, Sudhakar Muvvala3, Ramana D. Venkata4, Panda Kanhu Charan5

1Ph.D Scholar, Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana-500007

2Professor, Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia

3Professor and Principal, Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014

4Professor and Principal, Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana–508252

5Associate Professor, Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally, Hyderabad, Telangana

*Corresponding Author E-mail: sahoo.chinmaya83@gmail.com

Online published on 31 October, 2018.

Abstract

The current research was designed to develop controlled porosity osmotic pump (CPOP) tablets of stavudine a nucleoside reverse transcriptase inhibitor for the treatment of acquired immune deficiency syndrome (AIDS) Wet granulation method was adopted for the development of tablet of 80 mg dose of stavudine for once daily. The formulated tablets were evaluated for pre compression parameters, post compression parameters, in vitro dissolution study and scanning electron microscopy study. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer Peppas and Hixon Crowell model. The results of optimized formulation releases drug up to 18 h in a controlled manner and follow Higuchi kinetics and which is independent of the pH and agitation intensity. Short term stability study at 40±2ºC/75±5% RH for three months was carried out and observed that the optimized formulation did not show any significant changes in hardness, friability, weight variation, drug content, in vitro dissolution study etc.

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Keywords

AIDS, wet granulation, in vitro dissolution study, stability study.

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