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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 3
First page : ( 133) Last page : ( 138)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00021.6

Formulation and Evaluation of Sustained Release Matrix Tablets using Drug Cytisine Isolated from Fava Beans to Quit Smoking

Venkataswamy M.*, Thahaseen Neha, Kareemuddin Md, Priyanka JP, Gari Jaggareddy, Reddy Manasa, Divyasri Shambhuni

Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

*Corresponding Author E-mail: venkataswamy.m@viper.ac.in

Online published on 31 October, 2018.

Abstract

The aim of the present research work was to quit smoking by cytisine tablets. The tablet was formulated using excipeints by direct compression method. In vitro drug release study was carried out in simulated gastric fluid (0.1 N Hcl) for the first 2h and in phosphate buffer (pH 6.8) for the next 10 h following USP apparatus II paddle method. In order to describe the cytisine release kinetics from individual tablet formulations, the corresponding dissolution data were fitted in various kinetic dissolution models are zero order, first order. The results indicated that the drug release characteristics from follow First order kinetics and the mechanism of drug release was both Swelling and diffusion.

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Keywords

GymnocladusCaesalpiniodeae, therapeutic, manipulation.

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