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Research Journal of Pharmaceutical Dosage Forms and Technology
Year : 2018, Volume : 10, Issue : 2
First page : ( 55) Last page : ( 59)
Print ISSN : 0975-234X. Online ISSN : 0975-4377.
Article DOI : 10.5958/0975-4377.2018.00010.1

Formulation and Evaluation of Prolong Release Tablet of Anti-hypertensive Drug

Choudhari Pradip*

HSBPVT's College of Pharmacy, Kashti

*Corresponding Author E-mail: pradeep.chaudhari83@gmail.com

Online published on 7 July, 2018.

Abstract

Formulation of Prolonged release dosage form has a slower absorption rate than immediate release formulation and shows minimal fluctuation in plasma levels during steady state dosing interval. Additionally, the Once-daily dosage regimen has better patient compliance. Prolonged release tablet of Anti-hypertensive drug with Eudragit RS 30 D using wet granulation method yielded optimum results and process parameters like granulation spray rate and compression machine rotor speed was found robust product development. Stability studies showed that the formulation was stable after being kept at condition of 40° C±2°;C/75% RH, for period of 3 months. The formulated product gave a dissolution profile similar to that of the innovator product (f2 value>80).

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Keywords

Prolonged release dosage form, plasma levels, Eudragit RS, Stability studies, f2 value.

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