Antibacterial and wound healing activity of piper betle extracts against multidrug resistant strains
Nabar M. Bela*
Post Graduate, Department of Microbiology, Smt. Chandibai Himathmal Mansukhani College, Dist Thane, Maharashtra, Mumbai-400601, India
*Corresponding author e-mail: firstname.lastname@example.org
Online published on 12 January, 2018.
In the present study leaf extracts of the leaves of Piper betle were assessed for their antibacterial property against microorganisms resistant to broad spectrum antibiotics which were isolated from patients's skin and soft tissue infections. Hot and cold alcoholic extract of the betle leaves was found to be most effective against both the resistant and sensitive bacterial strains. Phytochemical components of the plant extract were identified and their antibacterial activity was studied against resistant and sensitive strains of Pseudomonas spp, Staphylococcus spp, Klebsiella spp, Enterobacter spp and Escherichia coli. The extract was then subjected to skin toxicity test using Sprague Dawley rats by Draize Shelanski method. It was noted that there was no erythema, edema or necrosis after 72 hours. The extract was then formulated into an appropriate ointment base for studying its wound healing properties by Incision wound model using Sprague Dawley rats. The formulation was effective in control of the infection as well as wound healing.
Piper betle, MDR, skin infections, Pseudomonas, Staphylococcus, Klebsiella, Enterobacter, Escherichia coli, wound healing, betel leaves.