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Medicinal Plants - International Journal of Phytomedicines and Related Industries
Year : 2015, Volume : 7, Issue : 3
First page : ( 227) Last page : ( 232)
Print ISSN : 0975-4261. Online ISSN : 0975-6892.
Article DOI : 10.5958/0975-6892.2015.00031.3

Phytochemical investigations and systematic exploration of anti-cancer potential of leaves of Nyctanthes arbor-tristis

Grover Parul1, Singh Shashank Kumar2, Suri K.A.3, Bansal Gulshan4,,*

1School of Pharmacy, KIET Group of Institutions, 13th Mile Stone, Delhi-Meerut Road, Ghaziabad, Uttar Pradesh, India

2Cancer Pharmacology Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu-180001, Jammu & Kashmir, India

3Indian Institute of Integrative Medicine, Jammu-180001, Jammu & Kashmir, India

4Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147002, Punjab, India

*Corresponding author: Gulshan Bansal, e-mail: gulshanbansal@rediffmail.com, gulshan@pbi.ac.in

Online published on 17 September, 2015.

Abstract

Leaves of Nyctanthes arbor -tr istis have been traditionally used as anti-cancer drug, but there is no report to support this tradi tional claim. The present study is undertaken to establish the anti-cancer activi ty of the N. arbortristis, and to identify the most active anticancer fraction(s) f rom its different extracts. Leaves of N. arbor -tr istis were extracted with solvents of varied polari ty (toluene, chloroform, ethylacetate and aqueous ethanol (HA), and subsequently evaluated for their anti-cancer activity against HL60 cell lines using MTT assay method. The toluene and HA extracts were fractionated through column chromatography and successive solvent extractions, respectively. All extracts, except ethyl acetate extract, exhibited potent anti-cancer activity. Four fractions of the toluene extract were found maximal ly potent whereas the petroleum ether f raction of HA was found responsible for anti-cancer activity of HA extract. I t is concluded that the plant can serve as an excel lent source of potent and probably new anti-cancer lead(s), which can be further modif ied chemically to produce a series of compounds for development of potent and safe anti-cancer drugs.

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Keywords

Nyctanthes arbor-tristis, anti-cancer, HL60 cell line, MTT assay.

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