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Medicinal Plants - International Journal of Phytomedicines and Related Industries
Year : 2022, Volume : 14, Issue : 4
First page : ( 597) Last page : ( 603)
Print ISSN : 0975-4261. Online ISSN : 0975-6892.
Article DOI : 10.5958/0975-6892.2022.00065.X

Phenolic composition and antioxidant potential of Cosmostigma cordatum

Das Asima, Mishra Mayuri, Jaison Juhi Puthukulangara, Sebastian Joseph Kadanthottu*

Department of Life Sciences, Christ University, Bangalore-560029, Karnataka, India

*Corresponding author e-mail: joseph.ks@christuniversity.in

Online Published on 30 November, 2022.


Cosmostigma cordatum (Poir.) M.R. Almeida, a plant belonging to the family Apocynaceae, has not been explored for its phytochemistry and antioxidant properties. Dried samples of leaves were used to estimate the proximate and mineral composition. Distilled water, methanol, and ethanol extracts were analyzed for the quantification of phenolic compounds and antioxidant potential. EC50 values were determined to estimate the antioxidant potential. Leaves of C. cordatum were found to be a good source of proximate contents and minerals. The total phenols, flavonoids, minerals, and antioxidant activity were determined from methanolic, ethanolic, and aqueous extracts of leaves. Extracts showed a higher concentration of phenols (2.29 ± 0.06 mg GAE g−1) in methanolic extracts and these extracts had higher antioxidant activity when compared to ethanol and aqueous extracts. The flavonoid content was higher in ethanolic extracts (51.94 ± 0.89 mg QE g−1) than in other extracts. In addition, gas chromatography-mass spectroscopy analysis of the hexane extract of leaves identified (E,E)7,11,15-trimethyl-3-methylene-hexadeca-1,6,10,14-tetraene, 1H-cycloprop[e]azulene, decahydro-1,1,7-trimethyl-4methylene-, n-hexadecanoic acid, 1-naphthalenepropanol,.alpha-ethenyldecahydro-2-hydroxy-.alpha.2,5,5,8a-pentamethyl [1R[1.alpha.(R*).beta.4a.beta.8a.alpha.]]-,cis-3,14-clerodadien-13-ol, squalene and octacosane. Our results suggest that the leaves can become a potential source of food supplements, nutraceuticals, and photo-therapeutics.



Cosmostigma, Phenolic compounds, Minerals, Antioxidant activity, DPPH.


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