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Journal of Veterinary Parasitology
Year : 2007, Volume : 21, Issue : 2
First page : ( 121) Last page : ( 124)
Print ISSN : 0971-6157.

Inhibitory effects of alcoholic extracts of Allium sativum and Piper longum on gross visual motility and glucose uptake of Fasciola gigantica and Gigantocotyle explanatum

Singh T.U.1, Kumar D.*, Gupta P.K., Tandan S.K.

Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar-243122, India.

*Corresponding author.

1Present address: College of Veterinary Science and Animal Husbandry, Mathura, India.

Abstract

Effects of alcoholic extract of bulbs of Allium sativum (Lahsun) and fruits of Piper longum (Peepli) were evaluated on gross visual motility and glucose uptake of Fasciola gigantica and Gigantocotyle explanatum in vitro in order to develop effective herbal based anthelmintic. Both the flukes were incubated in different concentrations (100, 300, 1000 and 3000 μg ml−1 of the alcoholic extract of A. sativum and P. longum and at 4h, the gross visual motility of the flukes and glucose uptake were recorded and compared with that of control flukes. Alcoholic extract of P. longum completely inhibited the gross visual motility of the flukes at 1000 and 3000 μg ml−1 concentrations, whereas A. sativum extract inhibited the motility at 1000 μg ml−1 concentration. Glucose uptake of F. gigantica was significantly inhibited at 1000 and 3000 μg ml−1 concentrations of alcoholic extract of A. sativum and P. longum, as compared to control. The extracts also markedly reduced the glucose uptake of G. explanatum at 1000 and 3000 μg ml−1 concentrations. It is concluded that alcoholic extract of A. sativum and P. longum produced paralyzing effect on F. gigantica and G. explanatum which might be the end result of energy crisis following glucose uptake inhibition in both the flukes.

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Keywords

Fasciola giganticaGigantocotyle explanatumAllium sativumPiper longum, Alcoholic extract.

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