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Journal of Medical Erudite
Year : 2015, Volume : 3, Issue : 1
First page : ( 1) Last page : ( 13)
Print ISSN : 2278-1927. Online ISSN : 2349-2112.

The Study of Insulin Resistance in the Pathogenesis of Metbolic Resection

Ahirwar Ashok Kumar1,*, Keshri Pankaj Kumar2, Agarwal Shashikant3, Jain Anju4, Ahirwar Pradeep5, Prabhakar Nishant6, Jain Neha7, Goswami Binita8, Bhatnagar M.K.9, Bhatacharjee Jayashree10

1MBBS, MD, Senior Resident, Department of Biochemistry, AIIMS, New Delhi, E-mail: drashoklhmc@gmail.com

2MBBS, MD, Assistant Professor, Department of Physiology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, E-mail: pankajkumar.keshri0@gmail.com

3MBBS, MD, Associate professor, Department of Physiology, Jhalawar Medical College, Jhalawar, Rajasthan, E-mail: shweta221277@yahoo.co.in

4MBBS, MD, Director Professor, Head of Department, Department of Biochemistry, LHMC, New Delhi, E-mail: dranjujain57@gmail.com

5MBBS, Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh, E-mail: pradeepahirwar21@gmail.com

6MBBS, Junior Resident, Department of Pediatrics, NSCB Medical College and Hospital, Jabalpur, Madhya Pradesh, E-mail: dr.nishant1986@gmail.com

7MBBS, MD, Senior Resident, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College & Hospital, AMU, Aligarh, Uttar Pradesh, E-mail: nehanehajain1986@gmail.com

8MBBS, MD, DNB, Associate Professor, Department of Biochemistry, LHMC, New Delhi, E-mail: binita.dr@gmail.com

9MBBS, MD, Director Professor, Department of Medicine, LHMC, New Delhi, E-mail: drmkbhatnagar@gmail.com

10MBBS, MD, Principal, VMMC, New Delhi, E-mail: jayashreedr@gmail.com

*Address of correspondence: Room no. 3013, Department of Biochemistry, Third Floor, Teaching Block, AIIMS, Ansari Nagar, New Delhi-110027, Phone no.: +91-9654210832

Online published on 30 December, 2015.

Abstract

Background

The metabolic syndrome (MS) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease (CVD) and diabetes mellitus (DM). Insulin Resistance is the one of the main culprit involved in the pathogenesis of MS and its comorbidity like CVD and DM.

Objective

To study the insulin resistance among the study subjects.

Materials and Methods

We enrolled 50 diagnosed case of metabolic syndrome as per International Diabetes Federation (IDF) criteria and 50 healthy volunteers as control. Insulin resistance was assessed by measuring fasting serum Insulin levels, HOMA-IR.

Result

The difference in the mean fasting blood glucose levels, post prandial blood sugar, HbA1c, serum Insulin and HOMA-IR between the study group(181.3 ± 70.9 mg/dl), (232.4 ± 94 mg/dl), (8.56 ± 2.73%), (14.6 ± 13μIU/ml), (6.4 ± 7.1) and control group (96.3 ± 7.5 mg/dl), (140.74 ± 142 mg/dl), (6.6 ± 3%), (6.6 ± 3μIU/ml), (1.62 ± 0.753) were significant with levels being higher in study group then that of controls.

Conclusion

Our study demonstrated that insulin resistance is involved in etiopathogenesis of Metabolic syndrome. This could be therapeutic target for the development of drug which could alleviate Insulin resistance and prevent the development of Metabolic syndrome, cardiovascular disease and diabetes mellitus. This would be beneficial for the prior identification of high risk individuals as well as for the monitoring of the disease status by assessing the insulin resistance and recommending to adopt the healthy life style.

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Keywords

Metabolic syndrome, Obesity, Insulin Resistance, HOMA-IR.

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