The Study of Insulin Resistance in the Pathogenesis of Metbolic Resection
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The metabolic syndrome (MS) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease (CVD) and diabetes mellitus (DM). Insulin Resistance is the one of the main culprit involved in the pathogenesis of MS and its comorbidity like CVD and DM.
To study the insulin resistance among the study subjects.
Materials and Methods
We enrolled 50 diagnosed case of metabolic syndrome as per International Diabetes Federation (IDF) criteria and 50 healthy volunteers as control. Insulin resistance was assessed by measuring fasting serum Insulin levels, HOMA-IR.
The difference in the mean fasting blood glucose levels, post prandial blood sugar, HbA1c, serum Insulin and HOMA-IR between the study group(181.3 ± 70.9 mg/dl), (232.4 ± 94 mg/dl), (8.56 ± 2.73%), (14.6 ± 13μIU/ml), (6.4 ± 7.1) and control group (96.3 ± 7.5 mg/dl), (140.74 ± 142 mg/dl), (6.6 ± 3%), (6.6 ± 3μIU/ml), (1.62 ± 0.753) were significant with levels being higher in study group then that of controls.
Our study demonstrated that insulin resistance is involved in etiopathogenesis of Metabolic syndrome. This could be therapeutic target for the development of drug which could alleviate Insulin resistance and prevent the development of Metabolic syndrome, cardiovascular disease and diabetes mellitus. This would be beneficial for the prior identification of high risk individuals as well as for the monitoring of the disease status by assessing the insulin resistance and recommending to adopt the healthy life style.
Metabolic syndrome, Obesity, Insulin Resistance, HOMA-IR.