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Journal of Medical Erudite
Year : 2014, Volume : 2, Issue : 2
First page : ( 52) Last page : ( 63)
Print ISSN : 2278-1927. Online ISSN : 2349-2112.

Therapeutic Evaluation for Antihypertensive Effect of a Unani Formulation in the Treatment of Essential Hypertension

Siddiqui Mohammad Akhtar*,1, Khan Abbas Ali**, Ansari Shabnam***, Khan Qamar Alam***

*Department of Moalejat, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India

**Medical Officer, Ayurvedic and Unani services, Uttar Pradesh

***MD Scholar, Faculty of Medicine (U), Jamia Hamdard, New Delhi, India

1Corresponding Author: Dr. Mohammad Akhtar Siddiqui, Associate Professor, Department of Moalejat, Faculty of Medicine (Unani), Jamia Hamdard, New Delhi, India, E-mail: drmasjh@reddifmail.com

Online published on 3 June, 2015.

Abstract

Background

Essential hypertension (EH) is the most prevalent type of hypertension and worldwide health concern due to its strong association with cardiovascular accidents. Unani system of Medicine has been treating hypertension since decades.

Aim, Material & Methods

The objective was to examine the antihypertensive effect of a Unani formulation containing Tukhm-ekahu (Lactuca scariola Linn), Kishneez (Coriandrum sativum Linn.), Gul-e-nilofar (Nymphaea alba Linn.) & Asraul (Rauwolfia serpentina Linn) in human being, reinforced with dietary changes and moderate exercise. An open single arm clinical trial was conducted for 8 weeks in 30 pre and mildly hypertensive adults, age 20–60 y, not taking blood pressure (BP) lowering medications of any other system (allopathic, homeopathic or aurvedic). A standardized method was used to measure BP at each follow up.

Result

After 8 weeks, Unani formulation lowered both systolic and diastolic BP. (P ≤ 0.001). Complete symptomatic relief was achieved in 83.33% participants. After discontinuing the drug, follow up at 4 week’s post-trial, 46.67% participants maintained normotensive character.

Conclusion

Unani formulation, containing Tukhm-e-kahu (Lactuca scariola Linn), Kishneez (Coriandrum sativum Linn.), Gule- nilofar (Nymphaea alba Linn.) and Asraul (Rauwolfia serpentina Linn) used for the treatment in these cases have exhibited potential diuretic, sedative, hypotensive, hypnotic, vasodepressor, anti-arrhythmic and cardiac function hemodynamic activities, suggesting plausible mechanisms of action in these cases. Thus above result concluded its antihypertensive effect in EH.

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Keywords

Unani medicine, lactuca scariolacoriandrum sativumnymphaea albarauwolfia serpentina, essential hypertension.

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