Oxidative stress induction and Hepato-Renal malfunction among chronic exposure cases to the diesel combustion nanoparticles. Prasad D R Mahadeshwara1,*, Kumar Shashank2, Malini S S1 1Department of studies of Zoology, Manasa Gangothri, Mysore, Karnataka, India 2Department of Forensic Medicine & Toxicology, Mysore Medical College and Research Institute, Mysore, Karnataka, India *Corresponding author Department of studies of Zoology, Manasa Gangothri, Mysore, Karnataka, E mail: manudrp@gmail.com
Online published on 19 June, 2018. Abstract Introduction Although studies are available on hepato-renal toxicity, lipid peroxidation products and the antioxidant status in experimental animals, a detailed report on exposed individuals is meagre. We aimed to study the variation in oxidative stress markers and correlate with hepato-renal parameters among exposures. Method Oxidative stress status and hepato-renal activity were studied in blood samples obtained from 50 individuals who were exposed to diesel combustion nanoparticles with a minimum work history of 8 year in the age range of 32-60years. Controls were age-matched university students and people living in hilly and forest areas. They were evaluated for oxidative stress markers, including superoxide dismutase, catalase, lipid peroxidation in blood and hepato-renal activity parameters like serum levels of bilirubin, SGOT, SGPT, urea and creatinine. Results The results show increased oxidative stress markers and variation among the hepato-renal parameters. It is concluded that exposures to diesel combustion nanoparticles are exposed to more oxidative stress and associated with a significant stress on hepatic and renal tissues. Conclusion The measurement of serum levels of bilirubin, SGOT, SGPT, urea and creatinine among chronic exposures and correlating with oxidative stress markers can be a good monitoring factor, and is recommended to be performed in a regular manner. Top Keywords Diesel combustion nanoparticles, oxidative stress, superoxide dismutase, catalase, lipid peroxidation, hepato-renal stress. Top |