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Journal of Innovation in Pharmaceutical Sciences
Year : 2019, Volume : 3, Issue : 1
First page : ( 22) Last page : ( 28)
Online ISSN : 2581-5695.

Method Development and Validation of Ertugliflozin and Sitagliptin by Using Simultaneous Equation Method

Anjali M.*, Manaaz, Shreshta M., Prasanna R., Shrisha T., Kumar M. Sathish

Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dullapally, Hyderabad

*anjalimamidala9523@gmail.com

Online published on 27 September, 2019.

Abstract

A simple, Accurate, precise method was developed for the simultaneous estimation of the Sitagliptin and Ertugliflozin in Tablet dosage form. The present method involves the solving of simultaneous equations (Vierodt's method). This Method solving of simultaneous equations based on the measurement of absorbance at two wavelengths, 210 nm and 221nm which are the λmax values of SGT and ETR respectively in Mixture of 0.1% OPA buffer and acetonitrile. Both SGT and ETR shows linearity at all the selected wavelengths and obeys beer's law in the concentration range of between 7.0–42μg/ml and 4.2–6.3μg/ml at 210 nm and 221 nm respectively. Recovery studies for SGT and ETR were performed and the percentage recovery for both the drugs was obtained in the range of 100.34–99.95% respectively.

Assay of the Ertugliflozin and Sitagliptin were and found to be 98.68% and 99.37%respectively. This method shows good reproducibility and recovery with % RSD less than 2. Statistical validation of the data shows that the proposed methods can be successfully applied for the routine analysis of drugs in commercial tablets. Hence, it could be used in the analysis of laboratory samples and marketed formulations containing these two drugs in combined dosage form without the interference of common excipients.

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Keywords

Simultaneous equationmethod, Ertugliflozin, Sitagliptin.

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