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Journal of Innovation in Pharmaceutical Sciences
Year : 2017, Volume : 1, Issue : 2
First page : ( 44) Last page : ( 47)
Online ISSN : 2581-5695.

A Systematic Review on Pharmacological Significance of Adenosine-2 A And Dopamine-D2 Receptor Interaction In Drug Addiction

Chander Semwal Bhupesh*, Debapriya Garabadu

Department of Pharmacology, Institute of Pharmaceutical Research GLA University, Mathura, U.P.-281406, India

*Correspondence to: Bhupesh Chander semwal, Assi. Prof., Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, NH#2 Delhi Mathura Highway P.O. Chaumuhan, Pin-281406, U.P., India. Email: bhupesh115@gmail.com

Online published on 27 September, 2019.

Abstract

Addiction to a drug candidate is defined as its excessive intake that can be rewarding and reinforcing to an individual. Drug addiction can also develop socio-economical challenges which can hinder the overall growth of any country. Therefore, mechanism of development of drug addiction is a prime requirement in the current era. Recently, it has been proposed that allosteric receptor-receptor interactions in homo-and heteroreceptor complexes may form the molecular basis of drug addiction. It has been reported that cocaine abuse can alter the adenosine A2AR-dopamine D2R hetero complexes and their receptor-receptor interactions and thereby induce neural plasticity in the basal ganglia. It has also been suggested that the composition and allosteric plasticity of these complexes in the ventral striatopallidal neurons may play a significant role in the genesis of drug addiction. It has also been documented that adenosine 2A receptor (A2AR) agonists can reduce cocaine reward and cocaine seeking mainly through activation of antagonistic allosteric A2AR-dopamine D2R (D2R) interactions in A2AR-D2R heteroreceptor complexes. Additionally, it has been suggested that cocaine self-administration can reorganize A2AR and D2R into increased A2AR-D2R heteroreceptor complexes in the nucleus accumbens shell associated with increases in the D2R-sigma1R heteroreceptor complexes in the brain. This reorganization can contribute to the demonstrated anti-cocaine actions of A2A receptor agonists and the putative formation of A2AR-D2R-sigma1R heterocomplexes. In conclusion, adenosine A2AR-dopamine D2R interaction perhaps play a significant role in the development of drug addiction and their modulation may contribute towards the management of drug addiction

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Keywords

Drug addiction, Adenosine, Dopamine, A2AR-D2R complex.

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