Pesticide induced immune complex mediated glomerulonephritis in sheep Khurana R.1, Chauhan R.S.2 1Department of Veterinary Epidemiology and Preventive Medicine, CCS Haryana Agricultural University, Hisar-125 004, INDIA. 2Department of Veterinary Pathology, G.B. Pant University of Agriculture and Technology, Pantnagar-263 145, India. Abstract To assess the immunopathological effects of four insecticides on kidneys in sheep, 20 lambs of about 6 months of age were procured and divided randomly into five groups of 4 lambs each. One group was kept as control and four groups were given orally lindane (1.25 ppm), monocrotophos (0.025 ppm), carbofuran (2.5 ppm) and fenvalerate (1.25 ppm) daily for six months. All the animals were sacrificed after six months and their kidneys were collected in 10 percent formol sublimate for immunopathological examination. Kidney sections were stained with immunoperoxidase technique for detection of immune complexes. In group II, lindane fed, there was glomerulonephritis and deposition of immune complexes in glomeruli, whereas kidneys of other groups did not reveal the presence of immune complexes in glomeruli. Top Key words Kidney, insecticides, lambs, immune complex, glomerulonephritis. Top |