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Year : 2020, Volume : 22, Issue : si1
First page : ( 19) Last page : ( 24)
Print ISSN : 0972-0561. Online ISSN : 0973-9149. Published online : 2020  **.
Article DOI : 10.5958/0973-9149.2020.00003.9

Immunomodulatory Effects of Allium sativum (Garlic) in Poultry: An Overview

Verma Megha1Ph.D. Scholar, Saminathan M.2*Scientist, Sarah Robeena3Ph.D. Scholar, Rastogi S.K.1Professor & Head

1Department of Veterinary Physiology and Biochemistry, College of Veterinary and Animal Sciences (CVASC), Govind Ballabh Pant University of Agriculture and Technology (GBPUAT), Pantnagar, India

2Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India

3Toxicology Laboratory Department of Zoology, Govt. Raza P.G. College, Rampur, Uttar Pradesh, India

*Corresponding author e-mail id: drswamyvet@gmail.com

:  28  February,  2020; :  14  March,  2020; :  11  April,  2020.

ABSTRACT

Verma M, Saminathan M, Sarah R and Rastogi SK (2020). Immunomodulatory Effects of Allium sativum (Garlic) in Poultry: An Overview. Journal of Immunology Immunopathology, 22(1): 19-24.

The present review was compiled to reveal the immunomodulatory effects of Allium sativum (garlic) in poultry. The complex therapeutic property of garlic extract makes it one of the most promising phytobiotic used in poultry and other animal species. Garlic contains various organosulfur compounds include alliin, diallyl disulphide, (E-Z) ajoene compounds and dithiane. The aged ethanolic extract of garlic contains S-allylmercaptocysteine (SAM-C) and S-allyl-L-cysteine (SAC). These compounds have different medicinal properties which regulate the immune system, hypercholesterolaemia, growth rate, feed intake and feed conversion ratio among these therapeutic properties, immunomodulation is the key point of this review, due to the high residual effect of antibiotics in poultry and its byproducts. Garlic showed significant immunomodulatory activity by stimulating the proliferation of lymphocytes, antibody production and transition in cytokines secretion. The extracts of garlic also showed anti-inflammatory activity by downregulation of IL-10 and IL-12 in inflammatory bowel diseases and prevent the binding of IL-12 to its receptors present in natural killer cells and T cells. The conclusion of this review is that inclusion of garlic in the diet of poultry improves the immune status by stimulating the cells of immune system.

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Keywords:

Garlic, Allium sativum, Organosulfur compounds, Allicin, Immunomodulation, Poultry.

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