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Journal of Ecophysiology & Occupational Health
Year : 2008, Volume : 8, Issue : 3 & 4
First page : ( 195) Last page : ( 199)
Print ISSN : 0972-4397.

Protective effect of Cynodon dactylon against STZ induced hepatic injury in rats

Singh Santosh Kumar, Rai Prashant Kumar, Jaiswal Dolly, Rai Devendra K., Sharma Bechan, Watal Geeta

Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry; University of Allahabad, Allahabad, 211 002, India.

Department of Biochemistry, University of Allahabad, Allahabad-211 002, India.

Abstract

The present study was designed to investigate the hepatoprotective effect of aqueous extract of Cynodon dactylon, widely used in India as a traditional treatment for diabetes mellitus. Male Albino Wistar rats (180–220 g) were administered with streptozotocin (STZ, 50 mg/kg) intraperitoneally to induce experimental diabetes. Alkaline phosphatase (ALKP), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), creatinine (CRTN) and total protein (TP), urine sugar (US) and total haemoglobin (Hb) were estimated at the beginning and after 14 days of treatment. Daily oral administration of aqueous extract of Cynodon dactylon suspended in distilled water at 500 mg/kg dose almost normalized various biochemical parameters. This suggests that Cynodon dactylon can be used as a hepatoprotective agent.

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Key words

Alkaline phosphatase, Serum glutanate oxaloacietate transminase, Serum glutamate pyruwate transminase, Creatinine, Cynodon dectylon.

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