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Journal of Dental and Orofacial Research
Year : 2018, Volume : 14, Issue : 1
First page : ( 35) Last page : ( 40)
Print ISSN : 2347-2588. Online ISSN : 2347-2758.

Evaluation of In-Vivo Antioxidant Potential of Ecbolium viride (Forssk.) Alston Roots on Carbon Tetra Chloride Induced Oxidative Stress in Wister Rats

Babu V.L. Ashoka1,*, Arunachalam G.2, Madhavan Varadharajan3

Department of Pharmacognosy, PGP college of Pharmaceutical Sciences, Namakkal-637207, India

1Assistant. Professor, Department of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054

2Professor, Department of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054

3Professor and HoD, Department of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054

*Contact Author E-Mail: ashokababu.pc.ph@msruas.ac.in

Online published on 18 January, 2019.

Abstract

Aim

To evaluate the antioxidant activity of the methanolic extract of Ecbolium viride (Forssk.) Alston roots in vivo.

Methods

The levels of catalase, superoxide dismutase, thiobarbituric acid reactive substance and glutathione were estimated in Carbon tetra chloride treated rats.

Results

The extract at 400 mg/kg significantly increased the levels of catalase, superoxide dismutase and glutathione and significantly decreased the thiobarbituric acid reactive substance level when compared with the toxicant group.

Conclusion

These findings propose that the methanolic extract of Ecbolium viride (Forssk). Alston has persuasive antioxidant activity and can be used as antioxidant supplement which would be beneficial in the treatment of various diseases.

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Keywords

Ecbolium Viride (Forssk.) Alston, Catalase, Superoxide Dismutase, Glutathione.

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