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Asian Journal of Dairy and Food Research
Year : 2019, Volume : 38, Issue : 4
First page : ( 341) Last page : ( 346)
Print ISSN : 0971-4456. Online ISSN : 0976-0563.
Article DOI : 10.18805/ajdfr.DR-142

Anti-diabetic activity of egyptian celery apigenin

Barky Amira Ragab El*, Ezz Amany Abdel hamid, El-Said Karim Samy, Sadek Mohamed EL-Refaay1, Mohamed Tarek Mostafa

Biochemistry Unit Chemistry Department Faculty of Science, Tanta University, Egypt

1Chemistry Department Faculty of Science, Tanta University, Egypt

*Corresponding Author: Amira Ragab El Barky, Biochemistry Unit, Chemistry Department, Faculty of Science, Tanta University, Egypt, Email: amiramaram52@yahoo.com

Online published on 22 January, 2020.


Diabetes is a metabolic disorder that occurs due to a deficiency in insulin secretion, action or both of them. Apigenin is a potent antioxidant, found mainly in celery. Therefore, this study aimed to display the biological activity of apigenin and it is a role in lowering blood glucose levels. Apigenin has been extracted from celery and administrated daily to streptozotocin-diabetic rats for six weeks. Apigenin significantly minimizes blood glucose level, the activities of á-amylase, lipid profile and malondialdehyde in serum. On the other hand, liver glycogen has been elevated in diabetic rats that treated with apigenin. The histopathological and immunohistochemical results confirmed that apigenin can decrease degenerative changes in the pancreatic â-cells. So, this study, depicts that apigenin considers a hypoglycemic agent with the potency to normalize odd in the biochemical parameter of diabetes and keep the normal architecture of the islet cells of the pancreas.



Apigenin, Diabetes, Oxidative stress, Streptozotocin.


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