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Journal of Animal Research
Year : 2016, Volume : 6, Issue : 1
First page : ( 43) Last page : ( 47)
Print ISSN : 2249-5290. Online ISSN : 2277-940X.
Article DOI : 10.5958/2277-940X.2016.00008.5

Cytotoxic and Anticancer Activity of F. Racemosa Fruit Extract on MCF7 Human Breast Cancer Cell Line by SRB Method

Gavhane Dnyaneshwar S*, Moregaonkar Santosh D, Mhase Aniket K

Department of Pathology, Bombay Veterinary College, Mumbai, India

*Corresponding author: DS Gavhane; Email: mmaulivet@gmail.com

Online published on 18 March, 2016.

Abstract

Present study was aimed to investigate the in vitro cytotoxicity and anticancer activity of F. racemosa on MCF7 human breast cancer cell line. Effect of ethanolic extracts of tender fruits of F. racemosa on MCF7 human breast cancer cell lines by Sulphorodamine B (SRB) assay was carried out. Three observations viz. LC50, TGI, GI 50 were recorded. The absorbance was recorded on an Elisa plate reader at a wavelength of 540 nm with 690 nm. F. racemosa showed LC50, TGI and GI50 activity at ≥ 80 μg/ml concentration. Thus, it can be concluded that F. racemosa fruit extract hassome cytotoxic and anticancer activity (in vitro)at ≥ 80 μg/ml concentration of plant extract on MCF7 human breast cancer cell line.

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Keywords

F. racemosa, anticancer, cytotoxic effect, MCF7, Sulphorodamine B method.

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