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Journal of Applied Animal Research
Year : 2010, Volume : 37, Issue : 2
First page : ( 161) Last page : ( 165)
Print ISSN : 0971-2119. Online ISSN : 0974-1844.

Effect of Honey on Healing of Pseudomonas aeruginosa Infected Burn Wounds in Rat

Hazrati M.1, Mehrabani D.2,*, Japoni A.3, Montasery H.4, Azarpira N.5, Hamidian-shirazi A.R.6, Tanideh N.6

1College of Nursing and Midwifery, Iran.

2Gastroenterohepatology Research Center Department of Pathology, Nemazee Hospital, Iran.

3Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Iran.

4School of Pharmacy, Iran.

5Transplantation Research Center, Nemazee Hospital, Iran.

6Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

*For correspondence: Tel: +98-711-6474263; Fax: +98-711-6474263; E-mail: mehrabad@sums.ac.ir.

Received:  2  June,  2009; Accepted:  26  January,  2010.


To determine the effect of honey on healing of burn wounds infected with Pseudomonas aeruginosa, 57 male Sprague-Dawley 180–220 g rats were randomly divided into 3 equal groups (A-C). Group A (control) did not receive any treatment, group B was treated with honey and group C with silver sulfadiazine. After 24 h of burn production, 108 colony forming units (CFU) of toxigenic strains of P. aeruginosa (PA 103) were inoculated subcutaneously into the burnt area. Samples were obtained from the infected areas for the presence of P. aeruginosa on the 2nd, 7th, 14th and 21st d post burns. After 1, 2 and 3 weeks, the animals were sacrificed and burn areas were examined histologically. Bacterial count on the d 2 was 105P. aeruginosa. On d 7, 14 and 21, there was a significant decrease in the number of bacteria in groups B and C. Re-epithelization was significantly more in honey group on d 14 in comparison to silver sulfadiazine and the control. Based on this experiment, application of honey for treatment of burn site even infected with P. aeruoginosa could be safe. However, to clinically use this natural product more supportive trials are needed.



Honey, silver sulfadiazine, healing, antibacterial, Pseudomonas aeruginosa, burn, wound, rat.


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