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Year : 2016, Volume : 40, Issue : 1
First page : ( 47) Last page : ( 50)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2016 March 1.
Article DOI : 10.5958/0973-970X.2016.00008.0

Pathology of bisphenol A induced sub-acute toxicity in Albino rats

Karnam S.S.2, Ghosh R.C.2, Mondal M.1,2,*

2Department of Veterinary Pathology, College of Veterinary Science & AH (IGKV), Durg

1CG College of Veterinary Science & AH (NDVSU) Rewa, MP

*Corresponding author: email: drmondalmm@rediffmail.com

Received:  07  October,  2014; Accepted:  23  January,  2016.


A sub-acute toxicity study of Bisphenol A (BPA) was conducted to investigate its toxic potential on Albino rat. The doses chosen were 50, 200 and 600 mg/kg body weight for group III, IV and V, respectively and group II served as vehicle control and group I was normal control. At necropsy, BPA treated rats revealed petechial haemorrhages in liver, severe consolidation and pneumonia in lungs and slight decrease in size of spleen. Microscopically, haemorrhages were found in liver, lungs, heart, kidneys and brain. BPA treated rats revealed depletion of the lymphocytes in spleen and severe degenerative and necrotic changes in liver, heart and kidneys. Congestion and pneumonia were marked in lungs and necrosis of germinal layer and spermatogonial cells were noted in the seminiferous tubules of testes in BPA treated rats. It was concluded from the study that BPA acts as a potent hepatotoxic and nephrotoxic agent.



Albino rat, Bisphenol A toxicity, Pathomorphology.


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