Pathomorphological changes of induced acute alphamethrin toxicity in broiler chicks
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The present investigation was undertaken to study the acute toxicity of alphamethrin in broiler chicks and establish the approximate lethal dose (ALD) of alphamethrin by oral route in broiler chicks. Acute toxicity study of alphamethrin in broiler chicks was determined by approximate lethal dose method. Initially different arbitrary doses (200, 300, 450, 675, 1013 mg/kg body weight) of alphamethrin were given to a single broiler chick until the lowest lethal dose was obtained. The approximate lethal dose (ALD) of alphamethrin by oral route in broiler chicks was determined as 1013 mg/kg body weight. During acute toxicity the treated chicks manifested extreme dullness, depression, anorexia, open mouth breathing, incoordination in movement, resting the head on support, lacrimation followed by tremors, convulsion, coma and death within 25 minutes of administration. Grossly, there were congestion in most of the organs like liver, lungs, kidneys, heart, thigh muscle and spleen. Histopathologically, treated birds showed severe depletion of lymphocyte population from lymphoid organs, severe congestion in brain, degenerative and necrotic changes along with mononuclear cell infiltration in liver, congestion and haemmorhage in lungs and congestion, degeneration and necrosis in kidneys.
Acute toxicity, Alphamethrin, Broiler chicks, Pathology.