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Year : 2009, Volume : 33, Issue : 2
First page : ( 190) Last page : ( 192)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2009 December 1.

Amelioration of lead-induced nephrotoxicity by certain adaptogens in broilers

Kumar M. Ratan3, Reddy K. S.3,1, Reddy A. Gopala3,*, Anjaneyulu Y.3,2, Kalakumar B.3, Reddy G. Dilip3

3Department of Pharmacology & Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-500 030 (AP)

22Department of Pathology, College of Veterinary Science, Rajendranagar, Hyderabad-500 030 (AP)

1Faculty of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati

*Corresponding author e-mail: gopalareddy123@rediffmail.com

Abstract

An experimental study of 6 weeks duration was conducted on 15 groups of broilers to evaluate lead-induced nephrotoxicity and its amelioration by poly herbal formulation (PHF; stressroak), shilajith, amla and vit E + Se. Group 1 was maintained on based diet, 2 on PHF @ 1 g/kg feed, 3 on shilajith @ 100 mg/kg feed, 4 on amla @ 500 mg/kg feed and 5 on vit E (3000 mg/kg feed) + Se (0.3 mg/kg feed). Group 6 was maintained on lead @ 250 mg/kg feed for 42 days (6 weeks) and 7 on lead for 28 days and subsequently on basal diet. Groups 8, 9, 10 and 11 were given lead along with PHF, shilajith, amla and vit E + Se, respectively throughout the experiment for 6 weeks. Groups 12, 13, 14 and 15 were given lead containing diet for the first 4 weeks (28 days) and subsequently treated with PHF, shilajith, amla and vit E + Se, respectively. The activity ALP and the concentration serum creatinine were significantly (P < 0.05) increased and there were corresponding pathological lesions in kidney in the toxic control groups on histopathology and electron microscopy at the end of 4th week. However, following treatment, there was a significant (P<0.05) reversal in groups 12, 13, 14 and 15. Amongst the drugs in test, PHF (stressroak) was found superior owing to its synergistic antioxidant and adaptogenic herbs, followed by shilajith. Amla and vit E + Se, though reversed the toxicological manifestations to certain extent, followed in order.

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Keywords

Amla, Broilers, Nephrotoxicity, PHF, Selenium, Shilajith, Stressroak, Vitamin E.

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