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Year : 2009, Volume : 33, Issue : 1
First page : ( 73) Last page : ( 76)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2009 June 1.

Pathogenicity study of chicken anaemia virus isolated from a poultry flock of Maharashta State, India

Velmurugan B.2, Dhama K.2, Kataria J.M.2, Dash B. B.2, Singh S.D.2, Mahendran M.1,2,*

2Avian Diseases Section, Division of Pathology, Indian Veterinary Research Institute, Izatnagar (U.P.)

1Avian Disease Diagnostic Laboratory, Manjadi, Thiruvalla, Department of Animal Husbandry, Kerala

*Corresponding author


The present study reports the pathogenic potential of a recent isolate of chicken anaemia virus (CAV) obtained from a poultry flock of Maharashta state, India. In experimentally infected specific pathogen free day old chicks, Maharashtra CAV isolate produced consistent clinical signs, low haematocrit values, bone marrow aplasia and generalized lymphoid atrophy particularly of thymus and bursa along with histopathological lessions of lymphocyte degeneration and depletion from the lymphoid organs in almost all infected chicks at the peak of anaemic phase, which were typical of CIA virus infection. Mean PCV value was significantly low (15.00±1.2) at 14 day post infection (dpi) compared (31.89±1.08). Lesions were pronounced during the first 2 to 3 weeks of infection and thymus, bone marrow, liver and bursa tissues were positive for CAV-antigen when tested by indirect immunofluorescent test (IIFT) revealing characteristic intranuclear immunofluorescence. Results revealed that Maharashtra CAV isolate is pathogenic and immunosuppressive in nature, thus suitable prevention and control strategies need to be formulated accordingly.



Antigen detection, Chicken anaemia virus (CAV), Pathogenicity.


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