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Year : 2008, Volume : 32, Issue : 1
First page : ( 44) Last page : ( 45)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2008 June 1.

A review on glanders - A re-emerging zoonosis in India

Pawaiya R.V.S.1,*, Chauhan R.S.2

1Division of Pathology, Centre for Animal Disease Research and Diagnosis Indian Veterinary Research Institute, Izatnagar-243122, U.P.

2Centre for Animal Disease Research and Diagnosis Indian Veterinary Research Institute, Izatnagar-243122, U.P.

*Corresponding author E-mail: rvspawaiya@rediffmail.com

Abstract

Glanders is an ancient zoonosis of equines caused by Burkholderia mallei. Most of the developed countries had eradicated the disease during early twentieth century. The disease lingers on in other countries including India, and has started reemerging even in some developed countries. India has experienced a recent outbreak of glanders after a long period of latency. There have been some recent advances in the understanding of the disease, especially its pathogenesis and diagnosis and molecular characterization including genome sequencing of glanders bacilli. In spite of all these advances and knowledge updating, a suitable vaccine for effective control of the disease is still far from realization. The human course of infection being fatal in the absence of early detection and treatment, glanders organism is categorized as potential bioweapon and bioterror agent. All these aspects of glanders have been reviewed and discussed in detail.

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Keywords

Biological agent, Burkholderia mallei, Diagnosis, Equines, Glanders, Human, Pathogenesis, Pathology.

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