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Year : 2007, Volume : 31, Issue : 1
First page : ( 11) Last page : ( 16)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2007 June 1.

Implant pathology of polyvinylidene fluoride coate polyethylene terephthalate fabric in rabbits

Anilkumar T.V.1,, Shelma R.2, Joseph Roy2, Mohanan P.V.3, Muraleedharan C.V.4

1Experimental Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India

2Polymer Processing Laboratory, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India

3Toxicology Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India

4Division of Artificial Organs Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum-695 012, Kerala, India

†Corresponding author. E-mail: somvanshi@gmail.com

Abstract

Implant pathology of polyvinylidene fluoride (PVDF) coated polyethylene terephthalate fabric (PET) was studied in rabbits. The tissue response to the coated fabric was compared with that of an uncoated commercial biomaterial-grade fabric. The coating was aimed at enhancing the potential of PET for biomedical applications. The histopathologic response to PVDF-coated and uncoated fabric was similar in the rabbit model. Both these materials evoked chronic inflammation, fibrosis, granuloma and giant cell reaction. Quantification of the nature of tissue response was performed as per international norms. When assessed by international standards, the PVDF coated fabric was found biocompatible in view of specific applications of the biomaterial.

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Keywords

Implant pathology, Biomaterials, Surface modification, Polyvinylidene fluoride, Polyethylene terephthalate).

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