Anti-inflammatory Effects and Other Uses of Cyclamen Species: A Review Mohammed Ghaidaa Jihadi1, Hameed Imad Hadi2,*, Kamal Sabreen A.3 1Department of Biology, College of Science, University of Al-Qadisiyah, Hillah city, Iraq 2Biomedical Science Department, University of Babylon, College of Nursing, Hillah city, Iraq 3Department of Biology, College of Science for women, University of Babylon, Hillah city, Iraq *Corresponding Author: Imad Hadi Hameed Biomedical Science Department, University of Babylon, College of Nursing, Hillah city, Iraq; Phone: 009647716150716 E-mail: imad_dna@yahoo.com
Online published on 3 April, 2018. Abstract Cyclamen was traditionally classified in the family Primulaceae, was reclassified in the subfamily Myrsinoideae within the family Primulaceae. The aqueous extract obtained from the Cyclamen europaeum root-tuber is rich in saponins. These substances are known for their surfactant activity, which means they are adsorbed through the nasal mucosa without being absorbed into the bloodstream. The action of cyclamen extract is local, and it is never absorbed into the bloodstream, so there are no known medication interactions associated with it. This product can be prescribed both as a monotherapy and, if needed, in combined therapy with other medications for treating rhinosinusitis. These include antibiotics, corticosteroids and antihistamines. If use of another nasal spray is required, waiting 2 hours between the two products is recommended. The surfactant action of the cyclamen saponins on the nasal mucosa reduces surface tension, facilitating humidification of the zone in addition to the secretion of mucin by goblet cells. This fluidifies the mucous accumulated in the nasal cavity, facilitating its elimination and thereby relieving congestion. Top Keywords Cyclamen, species, Anti-inflammatory, Bioactive compounds, Applications. Top |