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Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 8
First page : ( 1174) Last page : ( 1180)
Print ISSN : 0976-0245. Online ISSN : 0976-5506.
Article DOI : 10.5958/0976-5506.2019.02055.2

Application of Gallic Acid Enhances Alveolar Socket Healing

Al-Mahammadawy Abdul Karim A1, Abdulla Emad H2, Al-Rifae Imad K Abbas3, Al-Hijazi Athraa Y3,*

1College of Dentistry, Mustansiriya University, Baghdad, Iraq

2College of Dentistry, IbnSina University of Medical Pharmaceutical Sciences, Baghdad, Iraq

3Al-Mustaqbal University College, Dentistry Department, Babel, Iraq

*Corresponding author: Athraa Y Al-Hijazi e.mail: athraayms@yahoo.com

Online published on 26 September, 2019.



Alveolar bone regeneration can be guided by the application of a Gallic acid following tooth extraction.

Aim of the study

The present study was designed to evaluate the histological and immunohistochemical aspects of socket healing in extraction site received Gallic acid, compared with control site that healed spontaneously.

Materials and Method

Twelfth Sprague-Dawley male rats were subjected for a surgical tooth extraction of upper central teeth of both sides. The right side be the control one as the socket healed spontaneously. while left side treated with 3μL of Gallic acid. The rats were scarified at 14and 28days post extraction. Socket healing was examined histologically and evaluate immuno-expression of osteocalcin.


Experimental site illustrates trabecular bones formation between the peripheral and central regions of the sockets at 14 day and increment of bone formation was observed, filled most of socket at 28 days. Results show intense positive expression of osteocalcin by bone cell in experimental group in comparisum to control. The results confirmed by statistic analysis of the data, which revealed a high significant difference in the mean of positive cells specifically at day 14 postoperative.


The present study, high lighted on osseo-inductive and angiogenesis effect of the local application of gallic acid in socket healing.



Alveolar bone, bone regeneration, socket healing, Gallic acid, osteocalcin, tooth extraction.


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