Comparative Study on Levels of Troponin (cTn), creatine Kinase-Muscle/brain (cK-Mb), and b-type natriuretic Peptide (bnP) in Patients with Acute Myocardial Infraction and congestive cardiac Failure Manikandan A.1, Meghana V2,*, Silambanan Santhi3 1MBBS Student, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Chennai, India 2Associate Professor, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Chennai, India 3Professor and Head, Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research, Chennai, India *Corresponding Author: Meghana V, MBBS Student, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, India, Email: docteurmeghana@gmail.com
Online published on 4 June, 2019. Abstract Background To diagnose a patient with acute myocardial infraction (AMI) and congestive cardiac failure (CHF), a physician measures patient's serum level of cardiac biomarkers such as, troponin (cTn), creatine kinase-muscle/brain (CK-MB), and B-type natriuretic peptide (BNP) in count, to a number of diverse other tests including an electrocardiogram (ECG). In this study, we compare the serum level of cTnT, CK-MB and BNP in patients with AMI and CHF. We analyzed the results to assess if Troponin T can be used independently to differentiate AMI from CCF. Materials and Method In a retrospective cross-sectional study at Sri Ramachandra Medical Center, the serum level of cTnT, CK-MB and BNP were evaluated in patients who have had an acute myocardial infraction or congestive cardiac failure. The study group consisted of 100 male and female subjects in two groups, 50 subjects diagnosed with acute myocardial infarction and 50 patients diagnosed with congestive cardiac failure. Mean and Standard deviation for the two groups was taken and their p-value was calculated using the Mann Whitney U Test. Results Troponin T (cTnT) level was elevated in both Acute MI and CCF; however, the elevation was more in AMI patients (p=0.022) compared to CHF, but not very significant. Other two biomarkers, CK-MB and BNP, did not show any significant difference between the two groups. Conclusion Higher levels of CTnT may be seen in AMI as compared to CHF and is indicative of progressive cardiovascular disease. Top Keywords Troponin (cTn), CK-MB, B-type natriuretic peptide (BNP), Myocardial infarction, Congestive cardiac failure. Top |