Anti-Oxidants and their Role in Disease Management Sridevi Pingali1,*, Budde Srujana1,*, T Neeraja1, M Bhagavan Raju1, Adapa Dattatreya2 1Department of Pharmaceutical Chemistry, Sri Venkateshwara College of Pharmacy, Osmania University, Madhapur, Hyderabad, Telangana, India 2Department of Microbiology, GITAM Institute of Sciences, GITAM University, Visakhapatnam, Andhra Pradesh, India *Corresponding e-mail: sri_pingala@yahoo.co.in, srujana33305@gmail.com
Online published on 19 November, 2018. Abstract Free radicals are produced in the body because of exposure to radiation, some environmental pollutants and as byproducts of normal metabolism. They can damage components of cell and result in various types of diseases because of their highly reactive nature. Free radicals are neutralized by different types of systems in the body which include antioxidant enzymes like glutathione peroxidase, catalase, and superoxide dismutase and small molecules of nutrient-derived antioxidant (vitamin C, flavonoids, vitamin E, carotenes, glutathione, taurine, and uric acid,). A delicate balance exists between antioxidants and free radicals in healthy individuals. In the present review, different methods of antioxidant activity and their role in the management of different diseases have been discussed. In some pathologic conditions like cancer and diabetes, the level of antioxidants falls below normal due to oxidative stress. Supplements of antioxidant for such conditions are expected to be beneficial. Regular consumption of antioxidant rich foods is the best preventive measure for certain diseases. Top Keywords Free radicals, Metabolism, Antioxidant activity, Antioxidant enzymes. Top |